I may be a fool, but I tend to trust Oprah. She's richer than God, but I do think she does give a lot where it's needed. So I like her idea for Katrina relief. She's donating 10 million dollars to help rebuild houses, and she's asking the rest of us to help make those houses homes. So on the site you can buy items--just like you would from a gift or wedding registry--that will then be given to the recipients of the new houses. And just like a registry, you can spend as much or as little as you can afford. (Some people can even pay for a whole damn house!)
It's kind of a nice option for donating. Instead of sending cash to an organizaton, you're buying someone a brand new toaster. And who doesn't love toast?